Systematic target prioritization and validation from genome-scale loss-of-function screens in large panels of human cancer cell lines

被引：0

作者：

Shibue, Tsukasa ^{[1
]}

Krill-Burger, John M. ^{[1
]}

Paolella, Brenton R. ^{[1
]}

Gaeta, Benjamin ^{[1
]}

Asfaw, Adhana ^{[1
]}

Dempster, Joshua M. ^{[1
]}

McFarland, James M. ^{[1
]}

Root, David E. ^{[1
]}

Boehm, Jesse S. ^{[1
]}

Tsherniak, Aviad ^{[1
]}

Hahn, William C. ^{[2
]}

Vazquez, Francisca ^{[1
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

CANCER RESEARCH | 2020年 / 80卷 / 16期

关键词：

D O I：

10.1158/1538-7445.AM2020-LB-100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

LB-100

引用

页数：2

共 15 条

[1] Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
Glenn S Cowley
Barbara A Weir
Francisca Vazquez
Pablo Tamayo
Justine A Scott
Scott Rusin
Alexandra East-Seletsky
Levi D Ali
William FJ Gerath
Sarah E Pantel
Patrick H Lizotte
Guozhi Jiang
Jessica Hsiao
Aviad Tsherniak
Elizabeth Dwinell
Simon Aoyama
Michael Okamoto
William Harrington
Ellen Gelfand
Thomas M Green
Mark J Tomko
Shuba Gopal
Terence C Wong
Hubo Li
Sara Howell
Nicolas Stransky
Ted Liefeld
Dongkeun Jang
Jonathan Bistline
Barbara Hill Meyers
Scott A Armstrong
Ken C Anderson
Kimberly Stegmaier
Michael Reich
David Pellman
Jesse S Boehm
Jill P Mesirov
Todd R Golub
David E Root
William C Hahn
[J]. Scientific Data, 1
[2] Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
Cowley, Glenn S.
Weir, Barbara A.
Vazquez, Francisca
Tamayo, Pablo
Scott, Justine A.
Rusin, Scott
East-Seletsky, Alexandra
Ali, Levi D.
Gerath, William F. J.
Pantel, Sarah E.
Lizotte, Patrick H.
Jiang, Guozhi
Hsiao, Jessica
Tsherniak, Aviad
Dwinell, Elizabeth
Aoyama, Simon
Okamoto, Michael
Harrington, William
Gelfand, Ellen
Green, Thomas M.
Tomko, Mark J.
Gopal, Shuba
Wong, Terence C.
Li, Hubo
Howell, Sara
Stransky, Nicolas
Liefeld, Ted
Pang, Dongkeun
Bistline, Jonathan
Meyers, Barbara Hill
Armstrong, Scott A.
Anderson, Ken C.
Stegmaier, Kimberly
Reich, Michael
Pellman, David
Boehm, Jesse S.
Mesirov, Jill P.
Golub, Todd R.
Root, David E.
Hahn, William C.
[J]. SCIENTIFIC DATA, 2014, 1
[3] Systematic methods to identify cancer vulnerabilities from genome-wide loss-of-function screens: An interactive framework for target discovery
Krill-Burger, John M.
Borah, Ashir A.
Paolella, Brenton R.
McFarland, James M.
Vazquez, Francisca
[J]. CANCER RESEARCH, 2022, 82 (12)
[4] Erratum: Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
Glenn S Cowley
Barbara A Weir
Francisca Vazquez
Pablo Tamayo
Justine A Scott
Scott Rusin
Alexandra East-Seletsky
Levi D Ali
William F.J Gerath
Sarah E Pantel
Patrick H Lizotte
Guozhi Jiang
Jessica Hsiao
Aviad Tsherniak
Elizabeth Dwinell
Simon Aoyama
Michael Okamoto
William Harrington
Ellen Gelfand
Thomas M Green
Mark J Tomko
Shuba Gopal
Terence C Wong
Hubo Li
Sara Howell
Nicolas Stransky
Ted Liefeld
Dongkeun Jang
Jonathan Bistline
Barbara Hill Meyers
Scott A Armstrong
Ken C Anderson
Kimberly Stegmaier
Michael Reich
David Pellman
Jesse S Boehm
Jill P Mesirov
Todd R Golub
David E Root
William C Hahn
[J]. Scientific Data, 1 (1)
[5] Using genome-scale CRISPR-mediated loss-of-function and gain-of-function screens to analyze gene-drug interactions in cancer
Gilbert, Luke A.
Tanenbaum, Marvin E.
Horlbeck, Max A.
Adamson, Britt
Villalta, Jacqueline E.
Vale, Ronald D.
Kampmann, Martin
Weissman, Jonathan S.
[J]. CANCER RESEARCH, 2015, 75 (22)
[6] Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies (vol 1, 140035, 2014)
Cowley, Glenn S.
Weir, Barbara A.
Vazquez, Francisca
Tamayo, Pablo
Scott, Justine A.
Rusin, Scott
East-Seletsky, Alexandra
Ali, Levi D.
Gerath, William F. J.
Pantel, Sarah E.
Lizotte, Patrick H.
Jiang, Guozhi
Hsiao, Jessica
Tsherniak, Aviad
Dwinell, Elizabeth
Aoyama, Simon
Okamoto, Michael
Harrington, William
Gelfand, Ellen
Green, Thomas M.
Tomko, Mark J.
Gopal, Shuba
Wong, Terence C.
Li, Hubo
Howell, Sara
Stransky, Nicolas
Liefeld, Ted
Jang, Dongkeun
Bistline, Jonathan
Meyers, Barbara Hill
Armstrong, Scott A.
Anderson, Ken C.
Stegmaier, Kimberly
Reich, Michael
Pellman, David
Boehm, Jesse S.
Mesirov, Jill P.
Golub, Todd R.
Root, David E.
Hahn, William C.
[J]. SCIENTIFIC DATA, 2014, 1
[7] Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies (vol 1, 140035, 2014)
Cowley, Glenn S.
Weir, Barbara A.
Vazquez, Francisca
Tamayo, Pablo
Scott, Justine A.
Rusin, Scott
East-Seletsky, Alexandra
Ali, Levi D.
Gerath, William F. J.
Pantel, Sarah E.
Lizotte, Patrick H.
Jiang, Guozhi
Hsiao, Jessica
Tsherniak, Aviad
Dwinell, Elizabeth
Aoyama, Simon
Okamoto, Michael
Harrington, William
Gelfand, Ellen
Green, Thomas M.
Tomko, Mark J.
Gopal, Shuba
Wong, Terence C.
Li, Hubo
Howell, Sara
Stransky, Nicolas
Liefeld, Ted
Jang, Dongkeun
Bistline, Jonathan
Meyers, Barbara Hill
Armstrong, Scott A.
Anderson, Ken C.
Stegmaier, Kimberly
Reich, Michael
Pellman, David
Boehm, Jesse S.
Mesirov, Jill P.
Golub, Todd R.
Root, David E.
Hahn, William C.
[J]. SCIENTIFIC DATA, 2014, 1
[8] Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions
Lord, Christopher J.
Quinn, Niall
Ryan, Colm J.
[J]. ELIFE, 2020, 9 : 1 - 37
[9] A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth
Meacham, Corbin E.
Lawton, Lee N.
Soto-Feliciano, Yadira M.
Pritchard, Justin R.
Joughin, Brian A.
Ehrenberger, Tobias
Fenouille, Nina
Zuber, Johannes
Williams, Richard T.
Young, Richard A.
Hemann, Michael T.
[J]. GENES & DEVELOPMENT, 2015, 29 (05) : 483 - 488
[10] Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling
Ghaffari, Pouyan
Mardinoglu, Adil
Asplund, Anna
Shoaie, Saeed
Kampf, Caroline
Uhlen, Mathias
Nielsen, Jens
[J]. SCIENTIFIC REPORTS, 2015, 5

← 1 2 →