The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke

被引：49
|
作者：
Kang, Ruiqing [1 ,2 ]
Gamdzyk, Marcin [1 ]
Lenahan, Cameron [1 ]
Tang, Jiping [1 ]
Tan, Sheng [2 ]
Zhang, John H. [1 ]
机构：
[1] Loma Linda Univ, Sch Med, Dept Physiol & Pharmacol, Loma Linda, CA 92350 USA
[2] Southern Med Univ, Zhujiang Hosp, Dept Neurol, 253 Gongyedadaozhong, Guangzhou 510282, Peoples R China
来源：
CURRENT NEUROPHARMACOLOGY | 2020年 / 18卷 / 12期
关键词：
Blood-brain barrier; stroke; microglia; polarization; inflammation; endothelial cells; ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; SUBARACHNOID HEMORRHAGE; ISCHEMIC-STROKE; RAT-BRAIN; IMATINIB; DAMAGE; INJURY; MINOCYCLINE; MECHANISMS;
D O I：
10.2174/1570159X18666200529150907
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It is well-known that stroke is one of the leading causes of death and disability all over the world. After a stroke, the blood-brain barrier subsequently breaks down. The BBB consists of endothelial cells surrounded by astrocytes. Microglia, considered the long-living resident immune cells of the brain, play a vital role in BBB function. M1 microglia worsen BBB disruption, while M2 microglia assist in repairing BBB damage. Microglia can also directly interact with endothelial cells and affect BBB permeability. In this review, we are going to discuss the mechanisms responsible for the dual role of microglia in BBB dysfunction after stroke.
引用
收藏
页码：1237 / 1249
页数：13
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