Long-term safety and effectiveness of berotralstat (BCX7353) for the prophylaxis of hereditary angioedema (HAE) attacks: Results from the APeX-S study

被引：0

作者：

Kiani, Sorena ^{[1
]}

Wu, Adrian ^{[2
]}

Peter, Jonathan ^{[3
]}

Reshef, Avner ^{[4
]}

Maurer, Marcus ^{[5
]}

Stobiecki, Marcin ^{[6
]}

Kinaciyan, Tamar ^{[7
]}

Aygoeren-Puersuen, Emel ^{[8
]}

Best, Jessica ^{[9
]}

Cornpropst, Melanie ^{[9
]}

Sheridan, William P. ^{[9
]}

Farkas, Henriette ^{[10
]}

机构：

[1] Barts Hlth NHS Trust, London, England

[2] Ctr Asthma & Allergy, Hing Kong, Peoples R China

[3] Univ Cape Town, Allergy & Immunol Unit, Lung Inst, Cape Town, South Africa

[4] Barzilai Govt Hosp, Ashqelon, Israel

[5] Charite, Berlin, Germany

[6] Jagiellonian Univ, Med Coll, Krakow, Poland

[7] Med Univ Vienna, Vienna, Austria

[8] Goethe Univ, Univ Hosp Frankfurt, Frankfurt, Germany

[9] BioCryst Pharmaceut Inc, Durham, NC USA

[10] Semmelweis Univ, Budapest, Hungary

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 2021年 / 51卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

P033

引用

页码：172 / 173

页数：2

共 50 条

[1] Long-term effectiveness of berotralstat (BCX7353) for the prophylaxis of hereditary angioedema (HAE) attacks: Results from the APeX-S study
Reshef, A.
Maurer, M.
Kiani, S.
Wu, A. Y.
Stobiecki, M.
Kinaciyan, T.
Peter, J.
Aygoren-Pursun, E.
Cornpropst, M.
Nagy, E.
Murray, S.
Collis, P.
Farkas, H.
[J]. ALLERGY, 2020, 75 : 210 - 211
[2] Long-term safety and tolerability of Berotralstat (BCX7353) for Hereditary Angioedema (HAE) prophylaxis: APeX-S study results
Farkas, H.
Wu, A. Y.
Kiani, S.
Reshef, A.
Stobiecki, M.
Kinaciyan, T.
Maurer, M.
Aygoren-Pursun, E.
Dix, D.
Dobo, S.
Iocca, H.
Murray, S.
Sheridan, W. P.
Peter, J.
[J]. ALLERGY, 2020, 75 : 58 - 59
[3] Long-term safety and effectiveness of berotralstat for hereditary angioedema: The open-label APeX-S study
Farkas, Henriette
Stobiecki, Marcin
Peter, Jonny
Kinaciyan, Tamar
Maurer, Marcus
Aygoren-Pursun, Emel
Kiani-Alikhan, Sorena
Wu, Adrian
Reshef, Avner
Bygum, Anette
Fain, Olivier
Hagin, David
Huissoon, Aarnoud
Jesenak, Milos
Lindsay, Karen
Panovska, Vesna Grivcheva
Steiner, Urs C.
Zubrinich, Celia
Best, Jessica M.
Cornpropst, Melanie
Dix, Daniel
Dobo, Sylvia M.
Iocca, Heather A.
Desai, Bhavisha
Murray, Sharon C.
Nagy, Eniko
Sheridan, William P.
[J]. CLINICAL AND TRANSLATIONAL ALLERGY, 2021, 11 (04)
[4] Relative Reductions in Attack Rate With Prophylactic Berotralstat (BCX7353) in Subjects with Hereditary Angioedema (HAE): Responder Analysis from the APeX-2 Study
Lumry, William
Maurer, Marcus
Zuraw, Bruce
Banerji, Aleena
Riedl, Marc
Johnston, Douglas
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Jacobs, Joshua
Gower, Richard
Wedner, H. James
Sitz, Karl
Magerl, Markus
Cornpropst, Melanie
Elder, Jennifer
Iocca, Heather
Nagy, Eniko
Murray, Sharon
Collis, Philip
Sheridan, William
Christiansen, Sandra
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 145 (02) : AB105 - AB105
[5] Oral Prophylaxis with Berotralstat (BCX7353) Reduces Use of Standard of Care (SOC) On-demand Medication in Patients with Hereditary Angioedema (HAE): APeX-2 Study Results
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Zuraw, Bruce
Aygoren-Pursun, Emel
Li, Huamin
Busse, Paula
Johnston, Douglas
Maurer, Marcus
Lumry, William
Riedl, Marc
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Sitz, Karl
Gagnon, Remi
Clemons, Desiree
Dobo, Sylvia
Nagy, Eniko
Murray, Sharon
Collis, Philip
Sheridan, William
Banerji, Aleena
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 145 (02) : AB106 - AB106
[6] Berotralstat (BCX7353) treatment demonstrates robust and durable reduction in the rate of hereditary angioedema (HAE) attacks over 48 weeks of the phase 3 APeX-2 study
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Bernstein, J. A.
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Mcneil, D.
Cornpropst, M.
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Nagy, E.
Collis, P.
Craig, T.
[J]. ALLERGY, 2020, 75 : 457 - 458
[7] Long-term HAE Prophylaxis with Berotralstat Is Well Tolerated and Effective: Analysis for the APeX-S Study
Aygoeren-Puersuen, E.
Manning, M.
Fain, O.
Desai, B.
Tomita, D.
Johnston, D. T.
Li, H. H.
Kiani-Alikhan, S.
[J]. ALLERGOLOGIE, 2023, 46 (08) : 556 - 556
[8] BCX7353: AN EFFECTIVE AND SAFE ORAL PROPHYLAXIS AGAINST ATTACKS OF HEREDITARY ANGIOEDEMA. APEX-1 FINAL RESULTS
Aygoeren-Puersuen, E.
Bygum, A.
Panovska, V. Grivcheva
Steiner, U.
Huissoon, A.
Kinaciyan, T.
Fain, O.
Longhurst, H.
Farkas, H.
Fang, L.
Cornpropst, M.
Clemons, D.
Dobo, S.
Maurer, M.
Cicardi, M.
[J]. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2017, 119 (05) : E4 - E4
[9] Long-term HAE Prophylaxis with Berotralstat Is Well Tolerated and Effective: Analysis for the APeX-S Study
Aygoeren-Puersuen, Emel
Manning, Michael
Fain, Olivier
Desai, Bhavisha
Tomita, Dianne
Johnston, Douglas
Li, H. Henry
Kiani-Alikhan, Sorena
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2023, 151 (02) : AB129 - AB129
[10] Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE)
Kotian, Pravin L.
Wu, Minwan
Vadlakonda, Satish
Chintareddy, Venkat
Lu, Pengcheng
Juarez, Luis
Kellogg-Yelder, Debra
Chen, Xilin
Muppa, Saritha
Chambers-Wilson, Ramanda
Parker, Cynthia Davis
Williams, Jason
Polach, Kevin J.
Zhang, Weihe
Raman, Krishnan
Babu, Yarlagadda S.
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (17) : 12453 - 12468

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