Synthesis of dimeric lactose and dimeric (sialyl) LewisX glycolipids

被引:2
|
作者
Gege, C [1 ]
Schmidt, RR [1 ]
机构
[1] Univ Konstanz, Fachbereich Chem, D-78457 Constance, Germany
关键词
carbohydrate-carbohydrate interaction; Lewis antigen; neoglycolipids; molecular recognition;
D O I
10.1016/S0008-6215(02)00086-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To investigate structural requirements for the homophilic interaction between carbohydrates on planar model membranes, divalent derivatives with enforced proximity between the two carbohydrate epitopes (lactose, Lewis(X), and sialyl Lewis(X)) were synthesized by use of a dimeric membrane anchor as scaffold. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1089 / 1094
页数:6
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