Expect the unexpected: fungemia caused by uncommon Candida species in a Turkish University Hospital

被引：5
|
作者：
Alp, Sehnaz [1 ]
Gulmez, Dolunay [2 ]
Kardas, Riza Can [3 ]
Karahan, Gizem [1 ]
Tas, Zahit [1 ]
Gursoy, Gamze [1 ]
Ayaz-Ceylan, Caglayan Merve [1 ]
Arikan-Akdagli, Sevtap [2 ]
Akova, Murat [1 ]
机构：
[1] Hacettepe Univ, Fac Med, Dept Infect Dis & Clin Microbiol, TR-06100 Ankara, Turkey
[2] Hacettepe Univ, Dept Med Microbiol, Fac Med, Ankara, Turkey
[3] Hacettepe Univ, Dept Internal Med, Fac Med, Ankara, Turkey
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2021年 / 40卷 / 07期
关键词：
Uncommon Candida species; Fungemia; Antifungal treatment; Antifungal susceptibility; Breakthrough fungemia; Epidemiological cut-off value; ANTIFUNGAL SUSCEPTIBILITY; CANCER-PATIENTS; GUILLIERMONDII; EPIDEMIOLOGY; LUSITANIAE;
D O I：
10.1007/s10096-020-04147-5
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Fungemia caused by uncommon Candida species (UCS) (other than C.albicans, C.glabrata, C.parapsilosis, C.tropicalis, C.krusei) is a rare but emerging threat with their potential to exhibit reduced susceptibility or resistance to antifungal agents. We identified 25 patients with UCS fungemia (9 C.kefyr, 8 C.lusitaniae, 4 C.dubliniensis, 2 C.guilliermondii, 1 C.pelliculosa, 1 C.rugosa) through January 2011 and August 2018. Echinocandins were the most common administered agents, followed by fluconazole. Overall mortality was 44%. Echinocandins and voriconazole showed sufficient activity against all tested isolates. High fluconazole MICs among C.guilliermondii, C.pelliculosa, and C.rugosa were determined. MIC value of C.pelliculosa was above the epidemiological cut-off proposed for fluconazole.
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收藏
页码：1539 / 1545
页数：7
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