Asymmetric synthesis of 4H-1,3-oxazines: enantioselective reductive cyclization of N-acylated β-amino enones with trichlorosilane catalyzed by chiral Lewis bases

被引：53

作者：

Sugiura, Masaharu ^{[1
]}

Kumahara, Mako ^{[1
]}

Nakajima, Makoto ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Med & Pharmaceut Sci, Kumamoto 8620973, Japan

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 24期

关键词：

DERIVATIVES; EFFICIENT; CHLORIDE; KETONES; IMINES;

D O I：

10.1039/b905102c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-Acylated beta-amino enones reductively cyclize by treatment with trichlorosilane and a chiral Lewis base catalyst to afford optically active 4H-1,3-oxazines, which can be transformed to other chiral compounds without racemization.

引用

页码：3585 / 3587

页数：3

共 10 条

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