Invasive fungal infections in solid organ transplant recipients

被引:145
|
作者
Gavalda, J. [1 ]
Meije, Y. [1 ]
Fortun, J. [2 ]
Roilides, E. [3 ,4 ]
Saliba, F. [5 ]
Lortholary, O. [6 ,7 ]
Munoz, P. [8 ,9 ,10 ,11 ]
Grossi, P. [12 ]
Cuenca-Estrella, M. [13 ]
机构
[1] Hosp Univ Vall dHebron, Dept Infect Dis, Barcelona 08035, Spain
[2] Hosp Univ Ramon & Cajal, Dept Infect Dis, Madrid, Spain
[3] Aristotle Univ Thessaloniki, Fac Med, Dept Pediat 3, Infect Dis Unit,Sch Hlth Sci, GR-54006 Thessaloniki, Greece
[4] Hippokrateion Hosp, Thessaloniki, Greece
[5] Hop Paul Brousse, AP HP, Ctr Hepatobiliaire, Villejuif, France
[6] Univ Paris 05, Hop Necker Enfants Malad, Ctr Infectiol Necker Pasteur, Serv Malad Infect & Trop,IHU Imagine,CNRS URA3012, Paris, France
[7] Univ Paris 05, CNRS URA3012, Ctr Natl Reference Mycoses Invas & Antifong, Unite Mycol Mol,Inst Pasteur, Paris, France
[8] Hosp Gen Univ Gregorio Maranon, Madrid, Spain
[9] Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
[10] CIBER Enfermedades Resp CIBERES CB06 06 0058, Madrid, Spain
[11] Univ Complutense Madrid, Sch Med, Dept Med, Madrid, Spain
[12] Univ Insubria, Dept Surg & Morphol Sci, Infect Dis Sect, Varese, Italy
[13] Ctr Nacl Microbiol Virol & Inmunol Sanitarias Maja, Micol Serv, Madrid, Spain
关键词
Drug interactions; invasive aspergillosis; invasive candidiasis; solid organ transplantation; Transplant infectious disease; LIPOSOMAL AMPHOTERICIN-B; CLINICAL-PRACTICE GUIDELINES; BLOOD-STREAM INFECTIONS; BETA-D-GLUCAN; CRYPTOCOCCUS-NEOFORMANS INFECTION; ESCMID-ASTERISK GUIDELINE; HEMATOPOIETIC STEM-CELL; REAL-TIME PCR; RISK-FACTORS; ANTIFUNGAL PROPHYLAXIS;
D O I
10.1111/1469-0691.12660
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Solid organ transplant (SOT) recipients have a significant risk of invasive fungal diseases (IFD) caused mainly by Candida spp. and Aspergillus spp. Candida spp. is the most frequent agent of IFD in the transplant recipient. The absence of clinical trials and the epidemiological differences in IFD in different transplant programmes mean that there are no definitive recommendations for the diagnosis, treatment and prevention of IFD in SOT, so most of the evidence must be based on clinical experience.
引用
收藏
页码:27 / 48
页数:22
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