Synthesis of chiral sultams via palladiu-mcatalyzed intramolecular asymmetric reductive amination

被引：43
|
作者：
Song, Bo [1 ,2 ]
Yu, Chang-Bin [1 ]
Ji, Yue [1 ]
Chen, Mu-Wang [1 ]
Zhou, Yong-Gui [1 ,3 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 10期
基金：
中国国家自然科学基金;
关键词：
BORROWING HYDROGEN METHODOLOGY; PD-CATALYZED HYDROGENATION; EXCESS N-BUTYLLITHIUM; CYCLIC KETIMINES; ENANTIOSELECTIVE SYNTHESIS; COOPERATIVE CATALYSIS; SULFONYL KETIMINES; PHOSPHORIC-ACID; ALCOHOLS; RUTHENIUM;
D O I：
10.1039/c6cc09493g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel palladium-catalyzed intramolecular reductive amination of ketones with weakly nucleophilic sulfonamides has been developed in the presence of a Bronsted acid, giving a wide range of chiral gamma-, delta-, and epsilon-sultams in high yields and up to 99% of enantioselectivity.
引用
收藏
页码：1704 / 1707
页数：4
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