α,γ-Diamino acids:: Asymmetric synthesis of new constrained 6-amino-3-azabicyclo[3.2.1]octane-6-carboxylic acids

被引：22

作者：

Caputo, Francesco ^{[1
]}

Cattaneo, Cristian ^{[1
]}

Clerici, Francesca ^{[1
]}

Gelmi, Maria Luisa ^{[1
]}

Pellegrino, Sara ^{[1
]}

机构：

[1] Univ Milan, Fac Farm, Ist Chim Organ A Marchesini, I-20133 Milan, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 22期

关键词：

ALPHA-AMINO-ACIDS; PEPTIDE; DERIVATIVES; ANTAGONISTS; INHIBITORS; SCAFFOLDS; DESIGN; SYSTEM; ETHERS; SERIES;

D O I：

10.1021/jo061391o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of two new diastereomeric 6-amino-3-azabicyclo[3.2.1] octane-6-carboxylic acids exo- and endo-8,9 is reported using exo- and endo-norbornene amino acids as chiral building blocks. This method provides a fast access to optically pure amino acids 8 and 9 which can be considered both alpha,gamma- and alpha,delta-diamino acids containing sterical constraints and characterized by alpha,alpha-disubstitution.

引用

页码：8467 / 8472

页数：6

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