Combination of ziprasidone and clozapine in treatment-resistant schizophrenia

被引：13
|
作者：
Zink, M [1 ]
Mase, E [1 ]
Dressing, H [1 ]
机构：
[1] Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-68072 Mannheim, Germany
来源：
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | 2004年 / 19卷 / 04期
关键词：
clozapine; ziprasidone; schizophrenia; treatment resistance;
D O I：
10.1002/hup.580
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In cases of treatment-resistant schizophrenia the combined application of antipsychotic drugs often becomes necessary. Clozapine has been combined successfully with other atypical antipsychotic drugs such as risperidone or amisulpride in the past. We report the difficult treatment of a 28-year-old schizophrenic woman. Psychotic symptoms were found resistant to monotherapy with clozapine or ziprasidone. In contrast, combined application led to a marked improvement in both positive and negative symptoms of schizophrenia along with a decrease of side effects. The reported combination is a promising option in cases of treatment-resistant schizophrenia and should be further evaluated in prospective studies. Copyright (C) 2004 John Wiley Sons, Ltd.
引用
收藏
页码：271 / 273
页数：3
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