Palladium-catalyzed amination of aryl triflates

被引：204
|
作者：
Wolfe, JP [1 ]
Buchwald, SL [1 ]
机构：
[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 05期
关键词：
D O I：
10.1021/jo961915s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The conversion of aryl triflates to the corresponding aniline derivatives was accomplished in moderate to good yield using a catalyst consisting of the combination of palladium acetate (2 mol %) and either BINAP or Tol-BINAP. In contrast to the corresponding palladium-catalyzed amination of aryl bromides and iodides, electronically neutral aryl triflates gave higher yields of arylamines than did electron deficient aryl triflates, presumably due to the increased rate of base-promoted triflate cleavage in electron deficient substrates.
引用
收藏
页码：1264 / 1267
页数：4
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