In vivo tracking of cellular therapeutics using magnetic resonance imaging

被引：2
|
作者：
Long, Christoper M. [1 ]
Bulte, Jeff W. M. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Div MR Res, Baltimore, MD 21218 USA
来源：
EXPERT OPINION ON BIOLOGICAL THERAPY | 2009年 / 9卷 / 03期
关键词：
cell migration; cell tracking; contrast agent; immunotherapy; magnetic resonance imaging; stem cells; SUPERPARAMAGNETIC IRON-OXIDE; MESENCHYMAL STEM-CELLS; BONE-MARROW; PROGENITOR CELLS; CONTRAST AGENTS; GENE-EXPRESSION; DENDRITIC CELLS; MRI DETECTION; LYMPHOCYTE TRAFFICKING; SATURATION-TRANSFER;
D O I：
10.1517/14712590802715723
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: The success of many cell-based therapies is highly dependent on the accurate delivery, dosing and trafficking of the cellular therapeutic. In vivo magnetic resonance (MR) cell tracking provides a means to non-invasively and longitudinally evaluate these parameters for cellular therapy. Objective: To provide an overview of MR cell tracking and how cellular therapeutics might be improved by utilizing this technology. Methods: We focused on the technologies utilized for stem cell and immunotherapies in preclinical models of disease. Results/conclusion: New technologies in MR cell tracking will soon take the field beyond preclinical studies and begin to show benefits in clinical trials of novel experimental cell-based therapies.
引用
收藏
页码：293 / 306
页数：14
相关论文
共 50 条
  • [1] Tracking immune cells in vivo using magnetic resonance imaging
    Eric T. Ahrens
    Jeff W. M. Bulte
    [J]. Nature Reviews Immunology, 2013, 13 : 755 - 763
  • [2] Tracking immune cells in vivo using magnetic resonance imaging
    Ahrens, Eric T.
    Bulte, Jeff W. M.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2013, 13 (10) : 755 - 763
  • [3] Bacteria tracking by in vivo magnetic resonance imaging
    Hoerr, Verena
    Tuchscherr, Lorena
    Hueve, Jana
    Nippe, Nadine
    Loser, Karin
    Glyvuk, Nataliya
    Tsytsyura, Yaroslav
    Holtkamp, Michael
    Sunderkoetter, Cord
    Karst, Uwe
    Klingauf, Juergen
    Peters, Georg
    Loeffler, Bettina
    Faber, Cornelius
    [J]. BMC BIOLOGY, 2013, 11
  • [4] Sensitivity of magnetic resonance imaging of dendritic cells for in vivo tracking of cellular cancer vaccines
    Verdijk, Pauline
    Scheenen, Tom W. J.
    Lesterhuis, W. Joost
    Gambarota, Giulio
    Veltien, Andor A.
    Walczak, Piotr
    Scharenborg, Nicole M.
    Bulte, Jeff W. M.
    Punt, Cornelis J. A.
    Heerschap, Arend
    Figdorl, Carl G.
    de Vries, I. Jolanda M.
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2007, 120 (05) : 978 - 984
  • [5] Cell tracking using magnetic resonance imaging
    Hoehn, Mathias
    Wiedermann, Dirk
    Justicia, Carles
    Ramos-Cabrer, Pedro
    Kruttwig, Klaus
    Farr, Tracy
    Himmelreich, Uwe
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2007, 584 (01): : 25 - 30
  • [6] In vivo tracking of the human patella using cine phase contrast magnetic resonance imaging
    Sheehan, FT
    Zajac, FE
    Drace, JE
    [J]. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 1999, 121 (06): : 650 - 656
  • [7] Tracking and evaluation of dendritic cell migration by cellular magnetic resonance imaging
    Dekaban, Gregory A.
    Hamilton, Amanda M.
    Fink, Corby A.
    Au, Bryan
    de Chickera, Sonali N.
    Ribot, Emeline J.
    Foster, Paula J.
    [J]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2013, 5 (05) : 469 - 483
  • [8] Noninvasive tracking of cardiac embryonic stem cells in vivo using magnetic resonance imaging techniques
    Ebert, Steven N.
    Taylor, David G.
    Nguyen, Ha-Long
    Kodack, David P.
    Beyers, Ronald J.
    Xu, Yaqin
    Yang, Zequan
    French, Brent A.
    [J]. STEM CELLS, 2007, 25 (11) : 2936 - 2944
  • [9] Development of Clinically Applicable In Vivo Tracking of Extracellular Vesicles Using Magnetic Resonance Imaging (MRI)
    Sedrakyan, Sargis
    Akers, Johnny C.
    Soloyan, Hasmik
    Aguiari, Paola
    De Filippo, Roger E.
    Thu, Mya S.
    Perin, Laura
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022, 33 (11): : 433 - 433
  • [10] In vivo tumor redox imaging using magnetic resonance imaging
    Hyodo, Fuminori
    Krishna, Murali C.
    Mitchell, J. B.
    Utsumi, Hideo
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, 34 : S113 - S113
12345