Melanoma, Version 4.2014 Featured Updates to the NCCN Guidelines

被引：53

作者：

Coit, Daniel G. ^{[1
]}

Thompson, John A. ^{[2
]}

Andtbacka, Robert ^{[3
]}

Anker, Christopher J. ^{[3
]}

Bichakjian, Christopher K. ^{[4
]}

Carson, William E., III ^{[5
,6
]}

Daniels, Gregory A. ^{[7
]}

Daud, Adil ^{[8
]}

DiMaio, Dominick ^{[9
]}

Fleming, Martin D. ^{[10
]}

Gonzalez, Rene ^{[11
]}

Guild, Valerie ^{[12
]}

Halpern, Allan C. ^{[1
]}

Hodi, Stephen, Jr. ^{[13
]}

Kelley, Mark C. ^{[14
]}

Khushalani, Nikhil I. ^{[15
]}

Kudchadkar, Ragini R. ^{[16
]}

Lange, Julie R. ^{[17
]}

Martini, Mary C. ^{[18
]}

Olszanski, Anthony J. ^{[19
]}

Ross, Merrick I. ^{[20
]}

Salama, April ^{[21
]}

Swetter, Susan M. ^{[22
]}

Tanabe, Kenneth K. ^{[23
]}

Trisal, Vijay ^{[24
]}

Urist, Marshall M. ^{[25
]}

McMillian, Nicole R.

Ho, Maria

机构：

[1] Univ Utah, Mem Sloan Kettering Canc Ctr, Salt Lake City, UT 84112 USA

[2] Univ Utah, Fred Hutchinson Canc Res Ctr, Seattle Canc Care Alliance, Salt Lake City, UT 84112 USA

[3] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

[4] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[5] Ohio State Univ, Ctr Comprehens Canc, James Canc Hosp, Columbus, OH 43210 USA

[6] Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA

[7] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

[8] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

[9] Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA

[10] Univ Tennessee, St Jude Childrens Res Hosp, Hlth Sci Ctr, Knoxville, TN 37996 USA

[11] Univ Colorado, Ctr Canc, Boulder, CO 80309 USA

[12] Aim Melanoma, Richmond, CA USA

[13] Dana Farber Brigham & Womens Canc Ctr, Boston, MA USA

[14] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[15] Roswell Pk Canc Inst, Buffalo, NY USA

[16] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[17] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA

[18] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Evanston, IL 60208 USA

[19] Fox Chase Canc Ctr, Philadelphia, PA USA

[20] Univ Texas MD Anderson Canc Ctr, Houston, TX USA

[21] Duke Canc Inst, Durham, NC USA

[22] Stanford Canc Inst, Stanford, CA USA

[23] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[24] City Hope Comprehens Canc Ctr, Duarte, CA USA

[25] Univ Alabama, Birmingham Comprehens Canc Ctr, Tuscaloosa, AL 35487 USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2014年 / 12卷 / 05期

关键词：

RADIATION-THERAPY; ADJUVANT RADIOTHERAPY; CUTANEOUS MELANOMA; OPEN-LABEL; HIGH-RISK; PHASE-II; BRAF; LYMPHADENECTOMY; TEMOZOLOMIDE; IRRADIATION;

D O I：

10.6004/jnccn.2014.0066

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The NCCN Guidelines for Melanoma provide multidisciplinary recommendations for the management of patients with melanoma. These NCCN Guidelines Insights highlight notable recent updates. Dabrafenib and trametinib, either as monotherapy (category 1) or combination therapy, have been added as systemic options for patients with unresectable metastatic melanoma harboring BRAF V600 mutations. Controversy continues regarding the value of adjuvant radiation for patients at high risk of nodal relapse. This is reflected in the category 2B designation to consider adjuvant radiation following lymphadenectomy for stage III melanoma with clinically positive nodes or recurrent disease.

引用

页码：621 / 629

页数：9

共 50 条

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