Nicotinic acetylcholine receptors and the ascending dopamine pathways

被引：110

作者：

Livingstone, Phil D. ^{[1
]}

Wonnacott, Susan ^{[1
]}

机构：

[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

BIOCHEMICAL PHARMACOLOGY | 2009年 / 78卷 / 07期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Nicotine; Acetylcholine; Midbrain; Nucleus accumbens; Prefrontal cortex; VENTRAL TEGMENTAL AREA; MEDIAL PREFRONTAL CORTEX; FREELY MOVING RATS; GLUTAMATERGIC AXON-TERMINALS; SUBUNIT MESSENGER-RNAS; STRIATAL GABA RELEASE; IN-VIVO MICRODIALYSIS; BRAIN REWARD AREAS; NULL MUTANT MICE; C-FOS EXPRESSION;

D O I：

10.1016/j.bcp.2009.06.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in midbrain dopamine neurons that project to dorsal striatum, nucleus accumbens and prefrontal cortex. Thus nAChRs can influence the functions of these three pathways, notably motor control, 'reward' and executive function, respectively. Diverse subtypes of nAChRs have been identified on dopamine cell bodies and terminals as well as on neighbouring afferents and interneurons. Here we review the molecular and cellular mechanisms through which nAChRs exert their influence on these pathways in rodents. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：744 / 755

页数：12

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