Movin' on up:: the role of Ptdlns(4,5)P2 in cell migration

被引：117
|
作者：
Ling, Kun
Schill, Nicholas J.
Wagoner, Matthew P.
Sun, Yue
Anderson, Richard A.
机构：
[1] Univ Wisconsin, Sch Med, Dept Pharmacol, Program Mol & Cellular Pharmacol, Madison, WI 53706 USA
[2] Univ Wisconsin, Sch Med, Dept Pharmacol, Program Mol & Mol Biol, Madison, WI 53706 USA
来源：
TRENDS IN CELL BIOLOGY | 2006年 / 16卷 / 06期
关键词：
D O I：
10.1016/j.tcb.2006.03.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cell migration requires the coordination of many biochemical events, including cell-matrix contact turnover and cytoskeletal restructuring. Recent advances further implicate phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P-2] in the control of these events. Many proteins that are crucial to the assembly of the migration machinery are regulated by PtdIns(4,5)P-2. Coordinated synthesis of PtdIns(4,5)P-2 at these sites is dependent on the precise targeting of the type I phosphatidylinositol phosphate kinases (PIPKs). Two PIPKI isoforms target to, and generate, PtdIns(4,5)P-2 at membrane ruffles and focal adhesions during cell migration. Here, we discuss our current understanding of PtdIns(4,5)P-2 in the regulation of cell responses to migratory stimuli and how the migrating cell controls PtdIns(4,5)P-2 availability.
引用
收藏
页码：276 / 284
页数：9
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