Evidence for epoxidation by the chromium(VI)-glutathione system

被引：6
|
作者：
OBrien, P
Woodbridge, N
机构：
[1] Department of Chemistry, Imp. Coll. Sci., Technol. and Med., University of London, South Kensington
来源：
POLYHEDRON | 1997年 / 16卷 / 16期
关键词：
chromium(VI); glutathione; reduction; epoxidation;
D O I：
10.1016/S0277-5387(97)00017-X
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Oxygen-dependent epoxidation and oxidative cleavage of trans-beta-methylstyrene is shown to occur during reduction of chromium(VI) by glutathione. Oxygen-activated chromium(IV) or (V) intermediates are hence a possible pathway to the oxidative damage of DNA in vitro. (C) 1997 Elsevier Science Ltd.
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页码：2897 / 2899
页数：3
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