NBPF1 independently determine the risk stratification and prognosis of patients with neuroblastoma

被引：3
|
作者：
Zhang, Jing [1 ]
Zhao, Yuanyuan [2 ]
Wang, Jianhua [1 ]
Sneh, Tal [3 ]
Yu, Qianqian [1 ]
Zhou, Xiao [1 ]
Gong, Chen [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Oncol, Tongji Med Coll, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Organ Transplantat, Tongji Med Coll, Wuhan 430030, Peoples R China
[3] Arizona State Univ, Biodesign Inst, Ctr Mol Design & Biomimet, Tempe, AZ 85281 USA
来源：
GENOMICS | 2020年 / 112卷 / 06期
关键词：
Neuroblastoma; NBPF1; Risk stratification; Prognosis; Bioinformatics; N-MYC; CLASSIFICATION; EXPRESSION;
D O I：
10.1016/j.ygeno.2020.06.038
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Neuroblastoma is the most frequent extracranial malignant solid tumor in children, and the 5 year OS of high risk neuroblastoma patients was less than 15%. This study aimed to identify biomarkers for risk stratification and prognosis prediction in neuroblastoma.149 low risk samples, 108 intermediate risk samples and 619 high risk samples were included in our study, and NBPF1 gene was found to be significantly correlated with risk levels and OS. Significant negative correlations between NBPF1 and the expression of MYCN and AKT1S1, and positive correlations between NBPF1 and KIF1B expression were found, but only NBPF1 was an independent biomarker based on the construct of PPI for MYCN, NBPF1, KIF1B and AKT1S1 by STRING enrichment.
引用
收藏
页码：3951 / 3957
页数：7
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