Conjunctival fibrosis following filtering glaucoma surgery

被引：119
|
作者：
Schlunck, Guenther [1 ]
Meyer-ter-Vehn, Tobias [2 ]
Klink, Thomas [2 ]
Grehn, Franz [2 ]
机构：
[1] Univ Freiburg, Med Ctr, Ctr Eye, Killianstr 5, D-79106 Freiburg, Germany
[2] Wurzburg Univ Hosp, Dept Ophthalmol, Wurzburg, Germany
来源：
EXPERIMENTAL EYE RESEARCH | 2016年 / 142卷
关键词：
Fibrosis; Glaucoma; Surgery; Mechanotransduction; TGF-beta; Extracellular matrix; TISSUE-GROWTH-FACTOR; HUMAN TENONS FIBROBLASTS; INDUCED MYOFIBROBLAST TRANSDIFFERENTIATION; VASCULAR-PERMEABILITY FACTOR; VIVO CONFOCAL MICROSCOPY; ANTI-SCARRING AGENT; SMOOTH MUSCLE ACTIN; OPEN-ANGLE GLAUCOMA; FLUID SHEAR-STRESS; FILTRATION SURGERY;
D O I：
10.1016/j.exer.2015.03.021
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Despite advances in surgical technique and postoperative care, fibrosis remains the major impediment to a marked reduction of intraocular pressure without the need of additional medication (complete success) following filtering glaucoma surgery. Several aspects specific to filtering surgery may contribute to enhanced fibrosis. Changes in conjunctival tissue structure and composition due to preceding treatments as well as alterations in interstitial fluid flow and content due to aqueous humor efflux may act as important drivers of fibrosis. In light of these pathophysiological considerations, current and possible future strategies to control fibrosis following filtering glaucoma surgery are discussed. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：76 / 82
页数：7
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