Prep2:: Cloning and expression of a new prep family member

被引：20
|
作者：
Haller, K
Rambaldi, I
Kovács, EN
Daniels, E
Featherstone, M
机构：
[1] McGill Univ, McGill Canc Ctr, Montreal, PQ H3G 1Y6, Canada
[2] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada
[3] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3G 1Y6, Canada
[4] McGill Univ, Dept Med, Montreal, PQ H3G 1Y6, Canada
[5] McGill Univ, Dept Oncol, Montreal, PQ H3G 1Y6, Canada
来源：
DEVELOPMENTAL DYNAMICS | 2002年 / 225卷 / 03期
关键词：
Prep2; PKNOX2; PREP2; TALE; homeobox; homeodomain; Pbx; Hox; Meis; Prep1; PKNOX1; mouse; embryo; development;
D O I：
10.1002/dvdy.10167
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
We describe Prep2, a new murine homeobox-containing gene closely related to Prep1. The PREP2 protein belongs to the three amino acid loop extension (TALE) superclass of homeodomain-containing proteins and encodes a polypeptide of 462 residues. As for PREP1, PREP2 binds an appropriate site on DNA as a heterodimer with PBX1A. Northern analysis, immunoblotting, immunohistochemistry, and in situ hybridization show widespread Prep2 expression during organogenesis and in the adult. The data suggest that Prep2 functions to varying degrees in a broad array of tissues and developmental processes. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码：358 / 364
页数：7
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