Unimolecular artificial transmembrane channels showing reversible ligand-gating behavior

被引：10

作者：

Xiao, Qi ^{[1
]}

Haoyang, Wei-Wei ^{[1
]}

Lin, Tao ^{[1
]}

Li, Zhan-Ting ^{[1
]}

Zhang, Dan-Wei ^{[1
]}

Hou, Jun-Li ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, 220 Handan Rd, Shanghai 200433, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 07期

基金：

中国国家自然科学基金;

关键词：

ION-CHANNEL; TRANSPORT; CONSTRUCTION; SELECTIVITY; MODELS; METAL;

D O I：

10.1039/d0cc06974d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of peptide-appended bisresorcinarenes were synthesized, which adopted tubular conformation induced by intramolecular hydrogen bonds. The derivatives formed unimolecular artificial transmembrane channels in lipid bilayers to enable selective transport of monovalent cations. Importantly, the channels exhibited reversible ligand-gating behavior in response to alkyl amine and Cu2+.

引用

页码：863 / 866

页数：4

共 11 条

[1] Structural rearrangements underlying ligand-gating in Kir channels
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[2] Structural rearrangements underlying ligand-gating in Kir channels
Wang, Shizhen
Lee, Sun-Joo
Heyman, Sarah
Enkvetchakul, Decha
Nichols, Colin G.
NATURE COMMUNICATIONS, 2012, 3
[3] Unimolecular tubular artificial transmembrane channels
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ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
[4] Ligand-Gating by Ca2+ Is Rate Limiting for Physiological Operation of BKCa Channels
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Fakler, Bernd
JOURNAL OF NEUROSCIENCE, 2013, 33 (17): : 7358 - 7367
[5] Unimolecular artificial transmembrane channel with terminal dihydrogen phosphate groups showing transport selectivity for ammonium
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[6] Unimolecular artificial transmembrane channel with terminal dihydrogen phosphate groups showing transport selectivity for ammonium
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[7] Artificial ion channels showing rectified current behavior
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Yamamura, M
Satake, A
Kobuke, Y
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (49) : 12152 - 12159
[8] Allosteric Gating Determinants in the Transmembrane Domain of Pentameric Ligand-Gated Ion Channels
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Heusser, Stephanie A.
Bergh, Cathrine C.
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[9] A reversible single-molecule ligand-gating ion transportation switch of ON-OFF-ON type through a photoresponsive pillar[6]arene channel complex
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[10] The 7′ residue in the second transmembrane domain of ligand-gated ion channels influences receptor gating kinetics
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Das, P
Dillon, GH
BIOPHYSICAL JOURNAL, 2004, 86 (01) : 291A - 291A

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