Activation of mu opioid receptors in the ventrolateral periaqueductal gray inhibits reflex micturition in anesthetized rats

被引:22
|
作者
Matsumoto, S
Levendusky, MC
Longhurst, PA
Levin, RM
Millington, WR
机构
[1] Kinki Univ, Sch Med, Dept Urol, Osaka 5898511, Japan
[2] Samuel S Stratton Vet Affairs Med Ctr, Albany, NY 12208 USA
[3] Albany Med Coll Union Univ, Albany Coll Pharm, Dept Basic & Pharmaceut Sci, Albany, NY 12208 USA
[4] Albany Med Coll Union Univ, Albany Med Coll, Div Urol, Albany, NY 12208 USA
关键词
bladder; micturition; periaqueductat gray; opioid mu receptor; kappa receptor; urinary retention;
D O I
10.1016/j.neulet.2004.03.055
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This study tested the hypothesis that morphine and other opiates cause urinary retention by activating mu opioid receptors in the midbrain periaqueductal gray (PAG) region. Selective mu, delta and kappa receptor agonists were microinjected into the PAG of urethane-anesthetized rats and the amplitude and incidence of bladder contractions were recorded during continuous saline infusion. Arterial pressure was monitored through a femoral artery catheter. Microinjection of the mu receptor agonist DAMGO into the ventrolateral PAG (vlPAG) suppressed volume-evoked bladder contractions completely. Bladder contractions ceased within 5 min of DAMGO injection and remained essentially undetectable for the rest of the 20 min recording period. Microinjection of the delta receptor agonist DPDPE into the vlPAG did not significantly affect either the amplitude of bladder contractions or the time interval separating contractions. The kappa receptor agonist U-69593 caused no discernible change in amplitude but increased the interval between bladder contractions significantly. Microinjection of DAMGO, DPDPE or U-69593 into the lateral or dorsolateral PAG columns was ineffective. DAMGO injection into the vlPAG increased arterial pressure whereas DPDPE and U-69593 produced a small but significant depressor response. These data support the hypothesis that mu and kappa receptors in the vlPAG participate in the micturition reflex. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:116 / 119
页数:4
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