Four novel HLA alleles, DRB1*04: 11: 03, DRB1*10: 05, DRB1*15: 94 and DRB1*16: 22, identified in Brazilian individuals

被引:2
|
作者
Fabreti-Oliveira, R. A. [1 ,2 ,3 ]
Nascimento, E. [3 ,4 ]
Oliveira, C. K. F. [3 ]
Vale, E. M. G. [3 ]
Vilela, B. [3 ]
Santos, M. A. [2 ]
机构
[1] Univ Fed Minas Gerais, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Dept Ciencia Computacao, Belo Horizonte, MG, Brazil
[3] IMUNOLAB, Labo Imunol Transplantes, BR-30150281 Belo Horizonte, MG, Brazil
[4] Hosp Santa Casa Horizonte, Inst Ensino Pesquisas & Clin Transplantes, Belo Horizonte, MG, Brazil
关键词
POPULATION; DIVERSITY;
D O I
10.1111/iji.12091
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Four novel human leucocyte antigen (HLA) class II alleles were identified by sequencing-based typing (SBT) and analysis of the closest-matching alleles from volunteer subjects from the Brazilian Bone Marrow Donor Register (REDOME, Brazil). The new HLA alleles discovered include DRB1*04:11:03, DRB1*10:05, DRB1*15:94 and DRB1*16:22. Three of the novel alleles had single-nucleotide substitution polymorphisms when compared to their most homologous allele. Of these, one harboured a single-nucleotide polymorphism (SNP) identified as a silent substitution.
引用
收藏
页码:151 / 153
页数:3
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