NUSAP1 promotes invasion and metastasis of prostate cancer

被引：60

作者：

Gordon, Catherine A. ^{[1
]}

Gong, Xue ^{[1
,2
]}

Ganesh, Durga ^{[1
]}

Brooks, James D. ^{[1
,3
]}

机构：

[1] Stanford Univ, Sch Med, Dept Urol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA

来源：

ONCOTARGET | 2017年 / 8卷 / 18期

关键词：

NUSAP1; invasion; migration; metastasis; prostate cancer; ANDROGEN RECEPTOR GENE; ACTIVE-SURVEILLANCE; RADICAL PROSTATECTOMY; RETINOBLASTOMA GENE; EXPRESSION; AMPLIFICATION; PROGRESSION; PROGRAM; OVEREXPRESSION; MICROTUBULES;

D O I：

10.18632/oncotarget.15604

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have previously identified nucleolar and spindle associated protein 1 (NUSAP1) as a prognostic biomarker in early stage prostate cancer. To better understand the role of NUSAP1 in prostate cancer progression, we tested the effects of increased and decreased NUSAP1 expression in cell lines, in vivo models, and patient samples. NUSAP1 promotes invasion, migration, and metastasis, possibly by modulating family with sequence similarity 101 member B (FAM101B), a transforming growth factor beta 1 (TGF beta 1) signaling effector involved in the epithelial to mesenchymal transition. Our findings provide insights into the importance of NUSAP1 in prostate cancer progression and provide a rationale for further study of NUSAP1 function, regulation, and clinical utility.

引用

页码：29935 / 29950

页数：16

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