Expression of Fas-estrogen receptor fusion protein induces cell death in pancreatic cancer cell lines

被引：10

作者：

Kawaguchi, Y ^{[1
]}

Takebayashi, H ^{[1
]}

Kakizuka, A ^{[1
]}

Arii, S ^{[1
]}

Kato, M ^{[1
]}

Imamura, M ^{[1
]}

机构：

[1] KYOTO UNIV,DEPT PHARMACOL,FAC MED,SAKYO KU,KYOTO 606,JAPAN

来源：

CANCER LETTERS | 1997年 / 116卷 / 01期

关键词：

Fas; estrogen receptor; fusion protein; gene therapy; pancreatic cancer;

D O I：

10.1016/S0304-3835(97)04751-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, a novel system to induce apoptosis was reported. Fusion protein between Fas and the ligand-binding domain of the estrogen receptor (MfasER) could cause apoptotic cell death in an estrogen-dependent manner on murine fibrosarcoma L929 cells and human cervical carcinoma HeLa cells [1]. To investigate the application of this system to the gene therapy of pancreatic cancer, we introduced MfasER cDNA to six cell lines. Transiently expressed MfasER could cause cell death in all the cell lines tested. Furthermore, stably MfasER-expressing cells showed DNA fragmentation as early as 2 h and completely died in 48 h in the presence of estrogen. Combined with effective methods to introduce genes to pancreatic cancer selectively, MfasER would be a good tool for the gene therapy of pancreatic cancer in the future. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：53 / 59

页数：7

共 50 条

[1] Expression of Fas-estrogen receptor fusion protein in COS-7 cells
Lei Sun
[J]. 中国实验血液学杂志, 1997, (03) : 304 - 305
[2] A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines
Zhang, Jianqing
Riby, Jacques E.
Conde, Lucia
Grizzle, William E.
Cui, Xiangqin
Skibola, Christine F.
[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2016, 16
[3] A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines
Jianqing Zhang
Jacques E. Riby
Lucia Conde
William E. Grizzle
Xiangqin Cui
Christine F. Skibola
[J]. BMC Complementary and Alternative Medicine, 16
[4] Expression of an estrogen receptor alpha variant protein in cell lines and tumors
Fasco, MJ
Keyomarsi, K
Arcaro, KF
Gierthy, JF
[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2000, 162 (1-2) : 167 - 180
[5] Hypoxia induces VEGF expression in human pancreatic cancer cell lines
Burde, R
Barthel, B
von Lampe, B
Hoecker, M
Riecken, EO
Rosewicz, S
[J]. GASTROENTEROLOGY, 1999, 116 (04) : A383 - A383
[6] Reassessment of Estrogen Receptor Expression in Human Breast Cancer Cell Lines
Ford, Christopher H. J.
Al-Bader, Mate
Al-Ayadhi, Bushra
Francis, Issam
[J]. ANTICANCER RESEARCH, 2011, 31 (02) : 521 - 527
[7] Opioids induce expression of cell death receptor Fas
Yin, DL
Mufson, RA
Wang, RX
Shi, YF
[J]. FASEB JOURNAL, 1999, 13 (05): : A983 - A983
[8] Induction of estrogen receptor α-36 expression by bone morphogenetic protein 2 in breast cancer cell lines
Wang, Dingding
Huang, Peide
Zhu, Baowei
Sun, Li
Huang, Qing
Wang, Ju
[J]. MOLECULAR MEDICINE REPORTS, 2012, 6 (03) : 591 - 596
[9] Axl receptor tyrosine kinase expression in pancreatic cancer and pancreatic cancer cell lines.
不详
[J]. PANCREAS, 2004, 29 (04) : 360 - 361
[10] Raloxifene, a selective estrogen receptor modulator, induces apoptosis in bladder cancer cell lines
Kim, IY
Yu, JA
Kim, MM
Lerner, SP
[J]. JOURNAL OF UROLOGY, 2004, 171 (04): : 191 - 192

← 1 2 3 4 5 →