Lung donation after circulatory death

被引:26
|
作者
Ceulemans, Laurens J. [1 ,2 ,3 ]
Inci, Ilhan [3 ]
Van Raemdonck, Dirk [1 ,2 ]
机构
[1] Univ Hosp Leuven, Dept Thorac Surg, Herestr 49, B-3000 Leuven, Belgium
[2] Katholieke Univ Leuven, Dept Chron Dis Metab & Ageing, Leuven, Belgium
[3] Univ Hosp Zurich, Dept Thorac Surg, Herestr 49, CH-3000 Zurich, Switzerland
关键词
donation after circulatory death; lung transplantation; organ donation; HEART-BEATING DONORS; LONG-TERM OUTCOMES; CARDIAC-DEATH; CARDIOCIRCULATORY DEATH; BRAIN-DEATH; TRANSPLANTATION; PERFUSION; ARREST; CATEGORIES; EUTHANASIA;
D O I
10.1097/MOT.0000000000000627
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Purpose of review The current review presents a concise update on published literature on donation after circulatory death (DCD) and lung transplantation (LTx). Worldwide an increasing need for lungs is evident, however the utilization rate of DCD lung donors is still considerably low. In this summary article, we reviewed both the experimental background and international clinical experience. Recent findings Our analysis confirmed satisfactory results for LTx from DCD donors, which equals the results from donation after brain death. Although most studies reported on short-term results, some confirmed these results on the long-term and development of chronic lung allograft dysfunction. Our review summarizes the different DCD categories and underlines the potential of the DCD V category. We analyze the barriers to implement a DCD program, discuss the more recent advances like ex-vivo lung perfusion and describe the future challenges. Summary Based on the current short-term and long-term clinical results, we believe that barriers for DCD utilization should be overcome, resulting in a safe implementation of more DCD LTx programs worldwide.
引用
收藏
页码:288 / 296
页数:9
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