Palladium-catalyzed coupling of vinylogous amides with aryl halides: Applications to the synthesis of heterocycles

被引：102
|
作者：
Edmondson, SD [1 ]
Mastracchio, A [1 ]
Parmee, ER [1 ]
机构：
[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 08期
关键词：
D O I：
10.1021/ol000031z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Described herein is the first example of the palladium catalyzed coupling of vinylogous amides with aryl bromides and chlorides. The scope of this reaction with respect to the aryl component is investigated. Additionally, a tandem reaction sequence in which the above coupling is followed by an intramolecular Heck reaction is presented. These reactions can be applied to high yielding, one pot syntheses of nitrogen-containing heterocycles.
引用
收藏
页码：1109 / 1112
页数：4
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