Isolation and identification of two new compounds from marine-derived fungus Acremonium fusidioides RZ01

被引：0

作者：

An Xiao ^{[1
,2
]}

Feng Bao-Min ^{[3
]}

Chen Gang ^{[1
,2
]}

Chen Shao-Fei ^{[1
,2
]}

Wang Hai-Feng ^{[1
,2
]}

Pei Yue-Hu ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[3] Dalian Univ, Sch Life Sci & Biotechnol, Dalian 116622, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2016年 / 14卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Acremonium fusidioides; Chemical constituent; Steroid; Fusidione; NATURAL-PRODUCTS; ALCOHOLS;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Two new compounds, (22E)-25-carboxy-8 beta, 14 beta-epoxy-4a, 5a-dihydroxyergosta-2,22-dien-7-one (1) and fusidione (3), along with two known compounds, 5a, 8a-epidioxy ergosta-6,22-diene-3 beta-ol (2) and microperfuranone (4), were isolated from the fermentation products of the marine-sourced fungus Acremonium fusidioides RZ01. The structures of compounds 1 and 3 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Both new compounds showed inhibitory activity against HL-60 cells with IC50 values being16.6 and 44.9 mu mol.L-1, respectively.

引用

页码：934 / 938

页数：5

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