A translation repressor element resides in the 3′ untranslated region of human p53 mRNA

被引：35
|
作者：
Fu, LN
Ma, WL
Benchimol, S
机构：
[1] Princess Margaret Hosp, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada
来源：
ONCOGENE | 1999年 / 18卷 / 47期
基金：
英国医学研究理事会;
关键词：
p53; translational control; 3 ' UTR;
D O I：
10.1038/sj.onc.1203064
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 3' untranslated region of human p53 mRNA represses translation both irt vitro and in vivo. Here, we identify a cis-acting 66-nucleotide U-rich sequence in the human p53 mRNA 3' untranslated region that mediates translational repression. Using UV crosslinking, we detect a 40 kDa protein that interacts specifically with the p53 3'UTR containing the repressor element. Enhanced translation of p53 mRNA contributes to the accumulation of p53 protein in cells exposed to gamma-radiation and could be a consequence of relieving the inhibition mediated by the repressor element.
引用
收藏
页码：6419 / 6424
页数：6
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