Synthesis of 2,4,6-Triarylpyridines Using ZrOCl2 under Solvent-Free Conditions

被引：61

作者：

Moosavi-Zare, Ahmad Reza ^{[1
]}

Zolfigol, Mohammad Ali ^{[2
]}

Farahmand, Shohreh ^{[2
]}

Zare, Abdolkarim ^{[3
]}

Pourali, Ali Reza ^{[4
]}

Ayazi-Nasrabadi, Roya ^{[2
]}

机构：

[1] Univ Sayyed Jamaleddin Asadabadi, Asadabad 6541835583, Iran

[2] Bu Ali Sina Univ, Fac Chem, Hamadan 6517838683, Iran

[3] Payame Noor Univ, Dept Chem, Tehran, Iran

[4] Damghan Univ, Sch Chem, Damghan, Iran

来源：

SYNLETT | 2014年 / 25卷 / 02期

关键词：

pyridine; multicomponent reactions; zirconium; Krohnke pyridine; solvent-free; ONE-POT SYNTHESIS; SUBSTITUTED PYRIDINES; TRITYL CHLORIDE; NEUTRAL MEDIA; CATALYST; DERIVATIVES; INHIBITORS; AGENTS;

D O I：

10.1055/s-0033-1340088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient procedure for the synthesis of 2,4,6-triarylpyridines (Krohnke pyridines) by the one-pot multicomponent condensation of aldehydes (1 equiv) with acetophenones (2 equiv) and ammonium acetate (1.2 equiv) in the presence of catalytic amounts of oxozirconium(IV) chloride (ZrOCl2) under solvent-free conditions is described. In this work, four products have been reported for the first time. Easy work-up, simple methodology, clean reaction and reusability of the catalyst are some advantages of this work.

引用

页码：193 / 196

页数：4

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