The relationship among tensile strength, Young's modulus, and indentation hardness of pharmaceutical compacts

被引：70

作者：

Sun, Wei-Jhe ^{[1
]}

Kothari, Sanjeev ^{[2
]}

Sun, Changquan Calvin ^{[1
]}

机构：

[1] Univ Minnesota, Dept Pharmaceut, Coll Pharm, Pharmaceut Mat Sci & Engn Lab, 9-127B Weaver Densford Hall,308 Harvard St SE, Minneapolis, MN 55455 USA

[2] Ardelyx, 34175 Ardenwood Blvd,Suite 200, Fremont, CA 94555 USA

来源：

POWDER TECHNOLOGY | 2018年 / 331卷

关键词：

Mechanical property; Young's modulus; Hardness; Tensile strength; Microcrystalline cellulose; Dibasic calcium phosphate; POWDER COMPACTION; MICROCRYSTALLINE CELLULOSE; MECHANICAL-PROPERTIES; TRUE DENSITY; TABLETING PROPERTIES; CRYSTAL-STRUCTURE; ELASTIC RECOVERY; GRANULE SIZE; TABLETABILITY; POROSITY;

D O I：

10.1016/j.powtec.2018.02.051

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Mechanical properties of pharmaceutical materials, e.g., Young's modulus (E), indentation hardness (H), and tensile strength (sigma(t)), play an important role in powder compaction process. However, few studies investigated the relationship among these parameters and consequence for tablet compression. Using microcrystalline cellulose, a plastic material, and dibasic calcium phosphate anhydrate, a brittle material, as well as their binary mixtures, we systematically examined the relationship among the three properties. It was found that Young's modulus was proportional to indentation hardness (H/E approximate to 0.036) regardless of the composition and compaction pressure. For a given material, tensile strength was also proportional to E and H but the relationship varied with materials. Higher E and H were required to attain the same sigma(t) for a more brittle material. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

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