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Nanomaterials as a game changer in the management and treatment of diabetic foot ulcers

被引：37
|
作者：
Vellayappan, M. V. [1 ]
Jaganathan, S. K. [2 ,3 ,4 ]
Manikandan, A. [5 ]
机构：
[1] Univ Teknol Malaysia, Fac Biosci & Med Engn, Johor Baharu 81310, Malaysia
[2] Ton Duc Thang Univ, Dept Management Sci & Technol Dev, Tan Phong Ward, 19 Nguyen Huu Tho St,Dist 7, Ho Chi Minh City, Vietnam
[3] Ton Duc Thang Univ, Fac Sci Appl, Ho Chi Minh City, Vietnam
[4] Univ Teknol Malaysia, Fac Biosci & Med Engn, IJN UTM Cardiovasc Engn Ctr, Johor Baharu 81310, Malaysia
[5] Bharath Univ, Dept Chem, Madras 600073, Tamil Nadu, India
来源：
RSC ADVANCES | 2016年 / 6卷 / 115期
关键词：
OXIDE RELEASING NANOPARTICLES; ORAL-DRUG DELIVERY; GROWTH FACTOR-BB; NITRIC-OXIDE; IN-VIVO; OXIDATIVE STRESS; ACINETOBACTER-BAUMANNII; ELECTROSPUN NANOFIBERS; SKIN REGENERATION; WOUND MANAGEMENT;
D O I：
10.1039/c6ra24590k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nanoengineered biomaterials have tremendously improved the range of tools utilized for the control of as well as acceleration of healing of diabetic foot ulcers (DFU) over the last few decades. Despite nanoparticles and electrospun nanofibers being used extensively for the treatment of DFU, there has been no review available till now which addresses the utilization of the latest nanodelivery techniques along with modern electrospun nanofiber treatments for DFU. This review thoroughly summarizes the latest mindboggling findings of potential nanomaterials like polymeric and metallic nanoparticles and electrospun nanofibers for DFU treatment. In addition, a succinct insight into the potential of the aforementioned nanomaterials which can be exploited as therapeutic delivery agents for improving the regeneration of damaged dermal and epidermal tissues of DFU is underscored. Ultimately, current challenges and future prospects of nanoparticles and electrospun nanofibers for DFU treatment are highlighted.
引用
收藏
页码：114859 / 114878
页数：20
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