Capillary electrophoresis for the analysis of small-molecule pharmaceuticals

被引：80
|
作者：
Altria, Kevin
Marsh, Alex
Sanger-van de Griend, Carl
机构：
[1] GlaxoSmithKline R&D, Harlow CM19 5AW, Essex, England
[2] AstraZeneca Pharmaceut & Analyt R&D, Sodertalje, Sweden
来源：
ELECTROPHORESIS | 2006年 / 27卷 / 12期
关键词：
capillary electrophoresis; chiral separation; log P determination; pharmaceuticals; pK(a) determination;
D O I：
10.1002/elps.200600030
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
This paper reviews the application of CE to the analysis of small-molecule pharmaceuticals. The areas of pharmaceutical analysis covered are enantiomer separation, the analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, determination of related substances and physicochemical measurements such as log P and pK(a) of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details.
引用
收藏
页码：2263 / 2282
页数：20
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