DNA vaccines against COVID-19: Perspectives and challenges

被引：161
|
作者：
Silveira, Marcelle Moura [1 ]
Schmidt Garcia Moreira, Gustavo Marcal [2 ]
Mendonca, Marcelo [3 ]
机构：
[1] Fac Anhanguera, Dept Pharm, Pelotas, RS, Brazil
[2] Tech Univ Carolo Wilhelmina Braunschweig, Inst Biochem Biotechnol & Bioinformat, Braunschweig, Germany
[3] Fed Univ Agreste Pernambuco, Vet Med Course, Garanhuns, PE, Brazil
来源：
LIFE SCIENCES | 2021年 / 267卷
关键词：
Immunization; DNA vaccine; Nucleic acid-based vaccines; Coronavirus; COVID-19; PROTEIN; STRATEGIES; PATHOGENESIS; PREVENTION; DELIVERY; VIRUS; CELLS; SPIKE;
D O I：
10.1016/j.lfs.2020.118919
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is associated with several fatal cases worldwide. The rapid spread of this pathogen and the increasing number of cases highlight the urgent development of vaccines. Among the technologies available for vaccine development, DNA vaccination is a promising alternative to conventional vaccines. Since its discovery in the 1990s, it has been of great interest because of its ability to elicit both humoral and cellular immune responses while showing relevant advantages regarding producibility, stability, and storage. This review aimed to summarize the current knowledge and advancements on DNA vaccines against COVID-19, particularly those in clinical trials.
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页数：7
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