Azole resistance of Candida glabrata in a case of recurrent fungemia

被引：21
|
作者：
Posteraro, Brunella
Tumbarello, Mario
La Sorda, Marilena
Spanu, Teresa
Trecarichi, Enrico Maria
De Bernardis, Flavia
Scoppettuolo, Giancarlo
Sanguinetti, Maurizio
Fadda, Giovanni
机构：
[1] Univ Sacred Heart, Dept Microbiol, I-00168 Rome, Italy
[2] Univ Sacred Heart, Dept Infect Dis, I-00168 Rome, Italy
[3] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, I-00161 Rome, Italy
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2006年 / 44卷 / 08期
关键词：
D O I：
10.1128/JCM.00526-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We describe a case of recurrent Candida glabrata fungemia that became unresponsive to fluconazole treatment. Posttreatment isolates from blood and vaginal cultures of the immunocompetent patient were azole resistant and exhibited upregulated expression of CgCDR1/CgCDR2 efflux pumps compared to the original isolates. Amphotericin B therapy eradicated the infection.
引用
收藏
页码：3046 / 3047
页数：2
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