Environmental transmission of Mycobacterium ulcerans drives dynamics of Buruli ulcer in endemic regions of Cameroon

被引：20
|
作者：
Garchitorena, Andres [1 ,2 ]
Ngonghala, Calistus N. [3 ]
Texier, Gaetan [4 ,5 ]
Landier, Jordi [4 ,6 ]
Eyangoh, Sara [7 ]
Bonds, Matthew H. [3 ,8 ]
Guegan, Jean-Francois [1 ,2 ]
Roche, Benjamin [9 ]
机构：
[1] Univ Montpellier, IRD, CNRS, MIVEGEC,UMR 5290, F-34059 Montpellier, France
[2] Ecole Hautes Etud Sante Publ, Rennes, France
[3] Harvard Univ, Sch Med, Dept Global Hlth & Social Med, Boston, MA USA
[4] Reseau Int Inst Pasteur, Ctr Pasteur Cameroun, Serv Epidemiol & Sante Publ, Yaounde, Cameroon
[5] Aix Marseille Univ, Fac Med, INSERM, SESSTIM,IRD,UMR 912, Marseille, France
[6] Inst Pasteur, Unite Epidemiol Malad Emergentes, Paris, France
[7] Reseau Int Inst Pasteur, Ctr Pasteur Cameroun, Lab Mycobacteriol, Yaounde, Cameroon
[8] Stanford Univ, Dept Earth Syst Sci, Stanford, CA 94305 USA
[9] UPMC, IRD, UMMISCO, UMI 209, Bondy, France
来源：
SCIENTIFIC REPORTS | 2015年 / 5卷
关键词：
RISK-FACTORS; BORNE TRANSMISSION; DISEASE; INFECTION; INSECTS; PREVALENCE; OUTBREAK; PREDICTS; ECOLOGY; VECTOR;
D O I：
10.1038/srep18055
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Buruli Ulcer is a devastating skin disease caused by the pathogen Mycobacterium ulcerans. Emergence and distribution of Buruli ulcer cases is clearly linked to aquatic ecosystems, but the specific route of transmission of M. ulcerans to humans remains unclear. Relying on the most detailed field data in space and time on M. ulcerans and Buruli ulcer available today, we assess the relative contribution of two potential transmission routes -environmental and water bug transmission-to the dynamics of Buruli ulcer in two endemic regions of Cameroon. The temporal dynamics of Buruli ulcer incidence are explained by estimating rates of different routes of transmission in mathematical models. Independently, we also estimate statistical models of the different transmission pathways on the spatial distribution of Buruli ulcer. The results of these two independent approaches are corroborative and suggest that environmental transmission pathways explain the temporal and spatial patterns of Buruli ulcer in our endemic areas better than the water bug transmission.
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页数：9
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