A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis

被引：74
|
作者：
Newton, PN
Thai, LH
Tip, NQ
Short, JM
Chierakul, W
Rajanuwong, A
Pitisuttithum, P
Chasombat, S
Phonrat, B
Maek-A-Nantawat, W
Teaunadi, R
Lalloo, DG
White, NJ
机构：
[1] Mahidol Univ, Fac Trop Med, Bangkok, Thailand
[2] Sappasitprasong Hosp, Dept Med, Ubon Ratchathani, Thailand
[3] NE Reg Infect Dis Hosp, Khon Kaen, Thailand
[4] John Radcliffe Hosp, Nuffield Dept Clin Med, Ctr Trop Med, Oxford OX3 9DU, England
[5] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L69 3BX, Merseyside, England
[6] Inst Malariol Parasitol & Entomol, Ho Chi Minh City, Vietnam
[7] Inst Malariol Parasitol & Entomol, Qui Nhon, Vietnam
来源：
CLINICAL INFECTIOUS DISEASES | 2002年 / 35卷 / 06期
基金：
英国惠康基金;
关键词：
D O I：
10.1086/342299
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of greater than or equal to200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.
引用
收藏
页码：769 / 772
页数：4
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