Prospects of Optogenetic Prosthesis of the Degenerative Retina of the Eye

被引：6
|
作者：
Ostrovsky, M. A. [1 ,2 ]
Kirpichnikov, M. P. [3 ,4 ]
机构：
[1] Russian Acad Sci, Emanuel Inst Biochem Phys, Moscow 119334, Russia
[2] Lomonosov Moscow State Univ, Biol Fac, Dept Mol Physiol, Moscow 119991, Russia
[3] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
[4] Lomonosov Moscow State Univ, Biol Fac, Dept Bioengn, Moscow 119991, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2019年 / 84卷 / 05期
关键词：
optogenetics; channelrhodopsins; melanopsin; visual rhodopsin; degenerative retina; photoreceptors; bipolar cells; ganglion cells; RESTORES VISUAL RESPONSES; MICROBIAL RHODOPSINS; ECTOPIC EXPRESSION; GANGLION-CELLS; BIPOLAR CELLS; MOLECULAR PHYSIOLOGY; VISION RESTORATION; LIGHT RESPONSES; GENE-THERAPY; MOUSE MODEL;
D O I：
10.1134/S0006297919050031
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The review discusses the prospects of using rhodopsin as an optogenetic tool for prosthetics of degenerative (blind) eye retina and the principles of optogenetic techniques. Retinal-containing proteins that depolarize/hyperpolarize the plasma membrane of nerve cells and, accordingly, excite/inhibit physiological activity of neurons, are described. The problem of what cells of the degenerative retina can be treated with what particular rhodopsins is discussed in detail. Viruses and promoters required for the rhodopsin gene delivery into the degenerative retina cells are described. In conclusion, main concepts and tasks associated with the optogenetic prosthetic treatment of degenerative retina employing rhodopsins are presented.
引用
收藏
页码：479 / 490
页数：12
相关论文
共 50 条
  • [1] Prospects of Optogenetic Prosthesis of the Degenerative Retina of the Eye
    M. A. Ostrovsky
    M. P. Kirpichnikov
    [J]. Biochemistry (Moscow), 2019, 84 : 479 - 490
  • [2] Bicistronic Construct for Optogenetic Prosthesis of Ganglion Cell Receptive Field of Degenerative Retina
    L. E. Petrovskaya
    M. V. Roshchin
    G. R. Smirnova
    D. E. Kolotova
    P. M. Balaban
    M. A. Ostrovsky
    A. Y. Malyshev
    [J]. Doklady Biochemistry and Biophysics, 2019, 486 : 184 - 186
  • [3] Bicistronic Construct for Optogenetic Prosthesis of Ganglion Cell Receptive Field of Degenerative Retina
    Petrovskaya, L. E.
    Roshchin, M. V.
    Smirnova, G. R.
    Kolotova, D. E.
    Balaban, P. M.
    Ostrovsky, M. A.
    Malyshev, A. Y.
    [J]. DOKLADY BIOCHEMISTRY AND BIOPHYSICS, 2019, 486 (01) : 184 - 186
  • [4] PROSPECTS OF OPTOGENETIC PROSTHETICS OF A RETINA
    Firsov, M. L.
    [J]. ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA, 2017, 67 (05) : 53 - 62
  • [5] Subretinal prosthesis and optogenetic therapy: Functional validation on the primate retina.
    Picaud, S.
    [J]. ACTA PHYSIOLOGICA, 2017, 221 : 54 - 54
  • [6] Optogenetic approaches to retinal prosthesis
    Barrett, John Martin
    Berlinguer-Palmini, Rolando
    Degenaar, Patrick
    [J]. VISUAL NEUROSCIENCE, 2014, 31 (4-5) : 345 - 354
  • [7] Towards an Optogenetic Retinal Prosthesis
    McGovern, B. P.
    Palmini, R. Berlinguer
    Grossman, N.
    Neil, M.
    Drakakis, E.
    Degenaar, P. A.
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (13)
  • [8] Photostimulator for Optogenetic Retinal Prosthesis
    Grossman, N.
    Nikolic, K.
    Poher, V.
    McGovern, B.
    Drankasis, E.
    Neil, M.
    Toumazou, C.
    Degenaar, P.
    [J]. 2009 4TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING, 2009, : 68 - +
  • [9] Perspectives for the Optogenetic Prosthetization of the Retina
    Firsov M.L.
    [J]. Neuroscience and Behavioral Physiology, 2019, 49 (2) : 192 - 198
  • [10] Optogenetic Therapy for Retinal Degenerative Diseases
    Soheili, Zahra-Soheila
    [J]. JOURNAL OF OPHTHALMIC & VISION RESEARCH, 2023, 18 (04) : 348 - 350
12345