Enantioselective synthesis of NK-1 receptor antagonists (+)-CP-99,994 and (+)-CP-122,721

被引：37

作者：

Yamazaki, N ^{[1
]}

Atobe, M ^{[1
]}

Kibayashi, C ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 44期

关键词：

chiral oxime ethers; NK-1 receptor antagonist; CP-99,994; CP-122,721;

D O I：

10.1016/S0040-4039(02)01832-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective total synthesis of NK-1 receptor antagonists, (+)-CP-99,994 and (+)-CP-122,721, is described. The key steps are diastereoselective addition of vinyllithium to a chiral benzaldehyde oxime ether and diastereoselective borane reduction of a cyclic oxime ether. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7979 / 7982

页数：4

共 50 条

[1] CP-99,994, A NONPEPTIDE ANTAGONIST OF THE TACHYKININ NK(1) RECEPTOR
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[2] Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist
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[5] INTRATHECAL ADMINISTRATION OF CP-99,994, AN NK-1 RECEPTOR ANTAGONIST, PROTECTS AGAINST OUABAIN-INDUCED ARRHYTHMIAS
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[6] THE ANTIEMETIC EFFECTS OF CP-99,994 IN THE FERRET AND THE DOG - ROLE OF THE NK1 RECEPTOR
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[7] ANTAGONISM OF NOCICEPTIVE RESPONSES OF CAT SPINAL DORSAL HORN NEURONS IN-VIVO BY THE NK-1 RECEPTOR ANTAGONISTS CP-96,345 AND CP-99,994, BUT NOT BY CP-96,344
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[8] ANTIEMETIC PROFILE OF A NONPEPTIDE NEUROKININ-NK(1) RECEPTOR ANTAGONIST, CP-99,994, IN FERRETS
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