Preparation and Properties of ZnAl Layered Double Hydroxide/Polycaprolactone Nanocomposites for Use in Drug Delivery

被引：7
|
作者：
Wang, Hui [1 ]
Wu, Jiaqi [1 ]
Zheng, Lei [1 ]
Cheng, Xiaomin [1 ]
机构：
[1] Anhui Univ, Sch Chem & Chem Engn, Key Lab Environm Friendly Polymer Mat Anhui Prov, 111 Jiulong Rd, Hefei, Anhui, Peoples R China
来源：
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS | 2019年 / 58卷 / 10期
关键词：
Degradation; layered double hydroxide; nanocomposites; polycaprolactone; drug release; DOUBLE HYDROXIDE; DEGRADATION; DISPERSION; MORPHOLOGY; POLAR; LDH;
D O I：
10.1080/03602559.2018.1493121
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
ZnAl-layered double hydroxides (ZnAl-LDH)/polycaprolactone (PCL) nanocomposites were prepared by solution intercalation method. It is shown that lamellar ZnAl-LDH is randomly distributed in the PCL matrix with diameter of 60 nm. The addition of ZnAl-LDH decreases thermal decomposition temperature of composites, but improves the elastic modulus and tensile strength. The weight loss and release amount of diclofenac of ZnAl-LDH/PCL composites are higher than that of neat PCL. The drug release kinetics for nanocomposites and neat PCL could be described by first-order kinetic and Ritger- Peppas kinetic model. [GRAPHICS]
引用
收藏
页码：1027 / 1035
页数：9
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