Inflammatory Signaling in Necrotizing Enterocolitis

被引:55
|
作者
De Plaen, Isabelle G. [1 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Ann & Robert H Lurie Childrens Hosp Chicago, Div Neonatol,Dept Pediat,Childrens Hosp Chicago R, Chicago, IL 60611 USA
关键词
Necrotizing enterocolitis; Inflammatory mediators; Inflammation; TLR; Cytokines; Chemokines; PAF; NO; -; ROS; PLATELET-ACTIVATING-FACTOR; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE SYNTHASE; NEONATAL-RAT MODEL; ISCHEMIC BOWEL NECROSIS; INHIBITS ENTEROCYTE PROLIFERATION; INTESTINAL EPITHELIAL-CELLS; TOLL-LIKE RECEPTOR-4; FACTOR PAF-ACETHER;
D O I
10.1016/j.clp.2012.12.008
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The pathogenesis of necrotizing enterocolitis (NEC) is complex and its speed of progression is variable. To gain understanding of the disease, researchers have examined tissues resected from patients with NEC; however, as these are obtained at late stages of the disease, they do not yield clues about the early pathogenic events leading to NEC. Therefore, animal models are used and have helped identify a role for several mediators of the inflammatory network in NEC. In this article, we discuss the evidence for the role of these inflammatory mediators and conclude with a current unifying hypothesis regarding NEC pathogenesis.
引用
收藏
页码:109 / +
页数:17
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