Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells

被引:37
|
作者
Vidak, Marko [1 ]
Rozman, Damjana [1 ]
Komel, Radovan [1 ]
机构
[1] Univ Ljubljana, Fac Med, Inst Biochem, SI-1000 Ljubljana, Slovenia
来源
MOLECULES | 2015年 / 20卷 / 10期
关键词
food; dietary supplements; flavonoids; quercetin; catechins; proanthocyanidins; bioavailability; blood-brain barrier; glial cells; glioblastoma multiforme; GRAPE SEED PROANTHOCYANIDINS; BLOOD-BRAIN-BARRIER; GREEN TEA CATECHIN; PERFORMANCE LIQUID-CHROMATOGRAPHY; PHOSPHOLIPASE A(2) ACTIVITY; OXYGEN-GLUCOSE DEPRIVATION; HUMAN ENDOTHELIAL-CELLS; OXIDATIVE DNA-DAMAGE; ABERRANT CRYPT FOCI; PINE BARK EXTRACT;
D O I
10.3390/molecules201019406
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Quercetin, catechins and proanthocyanidins are flavonoids that are prominently featured in foodstuffs and dietary supplements, and may possess anti-carcinogenic activity. Glioblastoma multiforme is the most dangerous form of glioma, a malignancy of the brain connective tissue. This review assesses molecular structures of these flavonoids, their importance as components of diet and dietary supplements, their bioavailability and ability to cross the blood-brain barrier, their reported beneficial health effects, and their effects on non-malignant glial as well as glioblastoma tumor cells. The reviewed flavonoids appear to protect glial cells via reduction of oxidative stress, while some also attenuate glutamate-induced excitotoxicity and reduce neuroinflammation. Most of the reviewed flavonoids inhibit proliferation of glioblastoma cells and induce their death. Moreover, some of them inhibit pro-oncogene signaling pathways and intensify the effect of conventional anti-cancer therapies. However, most of these anti-glioblastoma effects have only been observed in vitro or in animal models. Due to limited ability of the reviewed flavonoids to access the brain, their normal dietary intake is likely insufficient to produce significant anti-cancer effects in this organ, and supplementation is needed.
引用
收藏
页码:19406 / 19432
页数:27
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