Effect of Preexisting Serum and Mucosal Antibody on Experimental Respiratory Syncytial Virus (RSV) Challenge and Infection of Adults

被引：66
|
作者：
Bagga, Bindiya [1 ,2 ,3 ]
Cehelsky, Jeffrey E. [4 ]
Vaishnaw, Akshay [4 ]
Wilkinson, Tom [5 ]
Meyers, Rachel [4 ]
Harrison, Lisa M. [1 ]
Roddam, Philippa L. [1 ,2 ,3 ]
Walsh, Edward E. [6 ,7 ]
DeVincenzo, John P. [1 ,2 ,3 ,8 ]
机构：
[1] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Memphis, TN 38103 USA
[2] Le Bonheur Childrens Hosp, Memphis, TN USA
[3] Childrens Fdn Res Inst, Memphis, TN USA
[4] Alnylam Pharmaceut, Cambridge, MA USA
[5] Univ Southampton, Fac Med, Clin & Expt Sci, Southampton SO9 5NH, Hants, England
[6] Univ Rochester, Sch Med & Dent, New York, NY USA
[7] Rochester Gen Hosp, New York, NY USA
[8] Univ Tennessee, Ctr Hlth Sci, Dept Mol Sci, Memphis, TN 38103 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2015年 / 212卷 / 11期
关键词：
respiratory syncytial virus; vaccines; serum antibody responses; mucosal antibody responses; correlates of protection; VIRAL LOAD; INFLUENZA; VACCINE; PROTECTION; IMMUNITY; INFANTS; DISEASE; HUMANS; RISK;
D O I：
10.1093/infdis/jiv281
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We studied preexisting respiratory syncytial virus (RSV)specific serum and nasal antibodies and their correlation with infectivity, viral dynamics, and disease severity in a human experimental infection model. Higher preinoculation serum neutralizing antibody titers and nasal immunoglobulin (Ig) A predicted lower infectivity and lower measures of viral replication. However, once individuals were infected, no significant protective effect of preexisting antibodies was seen. Lack of correlation between serum and mucosal antibodies was observed, implying that they are independent co-correlates of protection against RSV infection. We suggest that protection from RSV infection is a function of a complex interplay between mucosal and serum humoral immune responses.
引用
收藏
页码：1719 / 1725
页数：7
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