Gait and tremor investigation using machine learning techniques for the diagnosis of Parkinson disease

Parkinson's disease (PD) is a chronic and progressive movement disorder affecting patients in large numbers throughout the world. As PD progresses, the affected person is unable to control movement normally. Individuals affected by Parkinson's disease exhibit notable symptoms like gait impairments and tremor occurrences during different stages of the disease. In this paper a novel approach has been proposed to diagnose PD using the gait analysis, that consists of the gait cycle, which can be broken down into various phases and periods to determine normative and abnormal gait. Initially, the raw force data obtained from physionet database was filtered using a Chebyshev type 11 high pass filter with a cut-off frequency 0.8 Hz to remove noises arising from the changes in orientation of the subject's body and other factors during measurement. The filtered data was used for extracting various gait features using the peak detection and pulse duration measuring techniques. The threshold values of the gait detection algorithm were tuned to individual subjects. From the peak detection algorithm, various kinetic features including the heel and toe forces, and their normalized values were obtained. The pulse duration algorithm was developed to extract different temporal features including the stance and swing phases, and stride time. Tremor is a common symptom in PD. Tremor is an involuntary movement of body parts. At first the tremor may appear in a specific body part like an arm, leg or one side of the body and later it may spread to both sides. This rest tremor is a cardinal sign of PD. An average accuracy of 92.7% is achieved for the diagnosis of PD from gait analysis and tremor analysis is used for knowing the severity of PD. (C) 2018 Elsevier B.V. All rights reserved.