Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

被引：252
|
作者：
Scheiermann, Julia [1 ]
Klinman, Dennis M. [1 ]
机构：
[1] NCI, Canc & Inflammat Program, NIH, Frederick, MD 21702 USA
来源：
VACCINE | 2014年 / 32卷 / 48期
关键词：
CpG olignucleotide; Adjuvant; Infection; Cancer; Toll-like receptor; T-CELL RESPONSES; TOLL-LIKE RECEPTORS; HEPATITIS-B-VACCINE; APICAL MEMBRANE ANTIGEN-1; PHASE-I TRIAL; IMMUNOSTIMULATORY PHOSPHOROTHIOATE OLIGODEOXYRIBONUCLEOTIDE; BIOTHRAX(R) ANTHRAX VACCINE; BLOOD-STAGE VACCINE; SURFACE-ANTIGEN; IMMUNE-RESPONSES;
D O I：
10.1016/j.vaccine.2014.06.065
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Synthetic oligonucleotides (ODN) that express unmethylated "CpG motifs" trigger cells that express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells. CpG ODN induce an innate immune response characterized by the production of Thl and pro-inflammatory cytokines. Their utility as vaccine adjuvants was evaluated in a number of clinical trials. Results indicate that CpG ODN improve antigen presentation and the generation of vaccine-specific cellular and humoral responses. This work provides an up-to-date overview of the utility of CpG ODN as adjuvants for vaccines targeting infectious agents and cancer. Published by Elsevier Ltd.
引用
收藏
页码：6377 / 6389
页数：13
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