Alkynylation of benzonitriles via nickel catalyzed C-C bond activation

被引：60
|
作者：
Penney, JM [1 ]
Miller, JA [1 ]
机构：
[1] DSM Pharmaceut Chem, Greenville, NC 27834 USA
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 25期
关键词：
D O I：
10.1016/j.tetlet.2004.02.163
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The scope of synthetically useful nickel catalyzed cross coupling reactions of benzonitriles has now been expanded to allow alkynylation. Thus, the cross coupling of benzonitriles with alkynylzinc reagents occurs readily in the presence of Ni/PMe3 based catalysts to afford the respective aryl alkynes in high yields. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4989 / 4992
页数：4
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