CHRONIC PAIN FOLLOWING SPINAL CORD INJURY

被引：0
|
作者：
Masri, Radi [1 ]
Keller, Asaf [2 ]
机构：
[1] Univ Maryland, Baltimore Coll Dent Surg, Dept Endodont Prosthodont & Operat Dent, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Dept Anat & Neurobiol, Baltimore, MD 21201 USA
来源：
REGENERATIVE BIOLOGY OF THE SPINE AND SPINAL CORD | 2012年 / 760卷
关键词：
MOTOR CORTEX STIMULATION; ZONA INCERTA; NEUROPATHIC PAIN; SOMATOSENSORY THALAMUS; ALLODYNIA; NEURONS; MECHANISMS; PROJECTION; RESPONSES; INPUTS;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Most patients with insults to the spinal cord or central nervous system suffer from excruciating, unrelenting, chronic pain that is largely resistant to treatment. This condition affects a large percentage of spinal cord injury patients, and numerous patients with multiple sclerosis, stroke and other conditions. Despite the recent advances in basic science and clinical research the pathophysiological mechanisms of pain following spinal cord injury remain unknown. Here we describe a novel mechanism of loss of inhibition within the thalamus that may predispose for the development of this chronic pain and discuss a potential treatment that may restore inhibition and ameliorate pain.
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页码：74 / 88
页数：15
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