Procalcitonin as a marker of nosocomial infections in the neonatal intensive care unit

被引：30
|
作者：
Chiesa, C [1 ]
Pacifico, L [1 ]
Rossi, N [1 ]
Panero, A [1 ]
Matrunola, M [1 ]
Mancuso, G [1 ]
机构：
[1] Univ Rome La Sapienza, Inst Pediat, CNR, Inst Expt Med, I-00161 Rome, Italy
来源：
INTENSIVE CARE MEDICINE | 2000年 / 26卷
关键词：
procalcitonin; nosocomial infection; neonate;
D O I：
10.1007/BF02900733
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Objective: To determine accuracy of procalcitonin concentrations for diagnosing nosocomial infections in critically ill neonates. Design: Case-control study. Setting: Neonatal intensive care unit of a teaching hospital. Patients: Twenty-three neonates with nosocomial infection. Four controls matched for duration of hospital stay and birth date were chosen for each case patient. Measurements and results: PCT concentrations were measured by the LUMItest procalcitonin kit at onset of signs of infection and after recovery. Range of PCT concentrations (ng/ml) was 2.0 to 249.1 in case patients and 0.08 to 1.0 in controls (sensitivity and specificity, 100%). PCT values returned to normal (< 1.0 ng/ml) by day 3 to 7 of appropriate antibiotic therapy. Conclusions: Measurement of PCT concentrations may be useful for early diagnosis and monitoring of infectious complications in neonates during their stay in the neonatal intensive care unit.
引用
收藏
页码：S175 / S177
页数：3
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