A machine learning-based predictor for the identification of the recurrence of patients with gastric cancer after operation

被引:30
|
作者
Zhou, Chengmao [1 ,2 ,4 ]
Hu, Junhong [4 ]
Wang, Ying [1 ,4 ]
Ji, Mu-Huo [1 ,4 ]
Tong, Jianhua [1 ,4 ]
Yang, Jian-Jun [1 ,2 ,4 ]
Xia, Hongping [1 ,2 ,3 ,4 ]
机构
[1] Zhengzhou Univ, Dept Anesthesiol Pain & Perioperat Med, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China
[2] Southeast Univ, Sch Med, Nanjing 210009, Peoples R China
[3] Zhengzhou Univ, Dept Colorectal & Anal Surg, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China
[4] Nanjing Med Univ, Dept Pathol, Sch Basic Med Sci, Sir Run Run Hosp,State Key Lab Reprod Med,Key Lab, Nanjing 211166, Peoples R China
关键词
BODY-MASS INDEX; IMPACT; COMPLICATIONS; SURVIVAL;
D O I
10.1038/s41598-021-81188-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
To explore the predictive performance of machine learning on the recurrence of patients with gastric cancer after the operation. The available data is divided into two parts. In particular, the first part is used as a training set (such as 80% of the original data), and the second part is used as a test set (the remaining 20% of the data). And we use fivefold cross-validation. The weight of recurrence factors shows the top four factors are BMI, Operation time, WGT and age in order. In training group:among the 5 machine learning models, the accuracy of gbm was 0.891, followed by gbm algorithm was 0.876; The AUC values of the five machine learning algorithms are from high to low as forest (0.962), gbm (0.922), GradientBoosting (0.898), DecisionTree (0.790) and Logistic (0.748). And the precision of the forest is the highest 0.957, followed by the GradientBoosting algorithm (0.878). At the same time, in the test group is as follows: the highest accuracy of Logistic was 0.801, followed by forest algorithm and gbm; the AUC values of the five algorithms are forest (0.795), GradientBoosting (0.774), DecisionTree (0.773), Logistic (0.771) and gbm (0.771), from high to low. Among the five machine learning algorithms, the highest precision rate of Logistic is 1.000, followed by the gbm (0.487). Machine learning can predict the recurrence of gastric cancer patients after an operation. Besides, the first four factors affecting postoperative recurrence of gastric cancer were BMI, Operation time, WGT and age.
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页数:7
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