Scalable process for 4-(2-hydroxy-2-methyl)-ethyl-benzylamine

被引：3
|
作者：
Tucker, John L. [1 ]
Couturier, Michel
Castaldi, Michael J.
Chiu, Charles K. F.
Gestmann, Detlef
机构：
[1] Pfizer Inc, La Jolla Labs, Chem Res & Dev, San Diego, CA 92128 USA
[2] Pfizer Inc, Chem Res & Dev, Groton, CT 06340 USA
[3] CarboGen Labs, Aarau, Switzerland
来源：
SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 15期
关键词：
catalysis; oxidation; phase transfer;
D O I：
10.1080/00397910600636733
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The preparation of the title compound has been revisited and improved. Starting from inexpensive cuminonitrile, 4-(2-hydroxy-2-methyl)-ethyl-benzylamine is obtained in a scalable two-step process with an overall yield of 55%.
引用
收藏
页码：2145 / 2150
页数：6
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