Cascade C-N bond cleavage of amides/intramolecular amination reactions: an atom economical way to α-cabolin-4-ones

被引：5
|
作者：
Wang, Ye [1 ]
Zheng, Zhong [1 ]
Yuan, Yang [1 ]
Wang, Mengdan [1 ]
Guo, Zixia [1 ]
Jiang, Yuan-Ye [2 ]
Bai, Li-Ping [3 ,4 ]
Li, Yanzhong [1 ]
机构：
[1] East China Normal Univ, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China
[2] Qufu Normal Univ, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China
[3] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa 999708, Macau, Peoples R China
[4] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, Taipa 999708, Macau, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 03期
基金：
中国国家自然科学基金;
关键词：
COPPER; SAR;
D O I：
10.1039/d0qo01257b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An atom economical approach for the synthesis of alpha-carbolin-4-ones has been developed. This process was realized via a C-N bond cleavage/intramolecular amination cascade. During this process, one C-N and one C-C bond are cleaved and two C-N and two C-C bonds are formed. Mechanistic studies suggested a migrative N-cyclization process involving a carbene intermediate.
引用
收藏
页码：579 / 583
页数：5
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